I've dismantled the cube matrix, and gone back to double checking each individual LED assembly, due to the resistance reading I was getting. I checked continuity between the anode/cathode, cathode/cathode and anode/anode on each of the 8 assemblies. As I result I have replaced 7 LEDs that were allowing current to flow in the reverse direction, and then re-checked continuity. Everything as far as the LED matrix goes is now how it should be.
Checking pin 2 on U1 directly to ground gives an initial reading of around 1950 ohms, which slowly drops to 1750 ohms where it remains steady.
Pin 24 on the micro controller to ground shows open circuit, as does this pin to U1 pin 2!!
I will go and reflow Pin 24 and report back.